Benzo[a]pyrene prioritization
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چکیده
This is a compilation of abstracts of articles identified during the preliminary toxicological evaluation of evidence on the developmental and reproductive toxicity of benzo[a]pyrene (BaP, CAS# 50-32-8). BaP is a polycyclic aromatic hydrocarbon and a component of air pollution. Polycyclic aromatic hydrocarbons are formed as a result of incomplete combustion of organic materials and are ubiquitous environmental contaminants. Exposures to the general population occur through mainstream and environmental tobacco smoke, grilled and smoked foods, foods grown in polluted areas, drinking water, air, and coal tar-based pharmaceutical products. For non-smokers and those not occupationally exposed, the major source of exposure is diet.
منابع مشابه
ارزیابی میزان مواجهه تنفسی با بنزو آلفا پیرن(Benzo (a) Pyrene) در آسفالتکاران شهر تهران
Background: Asphalt workers are exposed to dangerous agents in his workplace that might result in occupational diseases. Benzo (a) pyrene as a human carcinogen, is emission from hot asphalt and asphalt workers are exposed with it. The aim of this study was, evaluation of respiratory exposure to benzo (a) pyrene among asphalt workers. Method: In this study, 42 samples were collected from breath...
متن کاملInduced Rat: The Influence of Plasma Lipoproteins and Albumin as Carrier Molecu le s I
In vitro studies have previously indicated that benzo(a)pyrene distributes primarily into the plasma lipoprotein fraction when incubated with whole plasma. Hydroxylated metabolites of benzo(a)pyrene distribute increasingly into the albumin fraction as the degree of metabolite hydroxylation increases. This report assesses the influence of plasma lipoproteins and albumin as carriers for benzo(a)p...
متن کاملReduction of Epoxy Derivatives of Benzo(a)pyrene by Microsomal Cytochrome P-4501
Benzo(a)pyrene 4,5-oxide was rapidly reduced to benzo(a)pyrene by rat liver microsomes in the presence of reduced nicotinamide adenine dinucleotide phosphate when incubated anaerobically. The activity of benzo(a)pyrene 4,5oxide reductase was increased about seven times by pretreat ment of rats with 3-methylcholanthrene. The addition of riboflavin to the incubation mixture resulted in the increa...
متن کاملHigh carcinogenicity of 2-hydroxybenzo(a)pyrene on mouse skin.
SUMMARY Benzo(a)pyrene and five isomenic phenols of benzo (a)pynene were tested for carcinogenicity by the topical application of 0.4 @moIe of each compound to the backs of C57BL/6J mice once every 2 weeks for 60 weeks. 1-, 3-, and 12-hydroxybenzo(a)pyrene were noncarcinogenic , 11-hy droxybenzo(a)pyrene was weakly carcinogenic, and 2-hy droxybenzo(a)pyrene and benzo(a)pyrene were highly car ci...
متن کاملReduction of epoxy derivatives of benzo(a)pyrene by microsomal cytochrome P-450.
Benzo(a)pyrene 4,5-oxide was rapidly reduced to benzo(a)pyrene by rat liver microsomes in the presence of reduced nicotinamide adenine dinucleotide phosphate when incubated anaerobically. The activity of benzo(a)pyrene 4,5oxide reductase was increased about seven times by pretreat ment of rats with 3-methylcholanthrene. The addition of riboflavin to the incubation mixture resulted in the increa...
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